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Decreased D2BP in the thalamus has been suggested, firstly, to lower thalamic gating thresholds, resulting in decreased filtering and autoregulation of information flow [31] and, secondly, to increase excitation of cortical regions through decreased inhibition of prefrontal pyramidal neurons [46], [47], [48].
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This finding suggests that chaplin peptides released into solution may alter the surface tension, rather than fibrils formed on the surface of aerial hyphae, consistent with a model where the chaplin peptides act firstly as surfactants to lower the surface tension of water and secondly to assemble into a hydrophobic layer that coats the hyphae [6], [16].
ChpE and ChpH, are thought to serve two functions - firstly acting as surfactants to lower the surface tension of water, then assembling (presumably by heteropolymerisation with the other short and long chaplins) into a hydrophobic layer that coats the emerging hyphae [6], [16].
Firstly, all letters are converted to lower case.
We therefore studied a large group of primary care patients presenting with signs of lower respiratory tract infection, firstly, to validate published diagnostic models for pneumonia and, secondly, to quantify whether CRP and procalcitonin concentrations add information to history and physical examination, and whether these could be combined in a clinically useful diagnostic tool.
Firstly, the startup wants to significantly lower the barriers for mobile app developers to market their wares.
Firstly, formation of polyborate anions lead to lower conductivity and lesser heat generation, and allowed higher running voltages.
Firstly, to make people laugh.
Firstly to attribute to quotes to Lord Sugar.
Firstly, to ensure the UK has secure energy supplies.
Firstly, to improve the health of the population.
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