Firstly, 68 patients enrolled in the first phase of the study made all assessments in a relatively short time period in a hospital setting, rather than repeated daily assessments over several days or weeks more likely to be used in a clinical research application.
Firstly, patients were enrolled from 8 of the 9 leading cancer centers in Peninsular Malaysia where cancer specialist manpower and physical infrastructure are concentrated.
Firstly, all patients were enrolled from a single university-affiliated hospital, and thus may not be able to represent all Chinese population affected by painful TMD.
Firstly, study sites were enrolled on a voluntary basis, which might introduce bias.
Firstly, not all patients enrolled in the Asthma Intervention Research Trial participated in long-term follow-up, although none of the reasons for non-participation was due to mortality.
Firstly, data were collected from adolescents enrolled in schools (the secondary education enrollment rate is 35% in Pakistan [ 21]) therefore results could not be generalized on youngsters not attending school that remains a major constraint of our study.
Firstly, the total number of gliomas enrolled in this study was small for evaluating the usefulness of this new tracer, especially low-grade glioma.
We aimed to investigate, firstly, how many people who initially enrolled in a DMP left the program again at a later time.
Firstly participating centres were at liberty to decide which patients they would enrol; subjects were not, therefore, enrolled consecutively, thereby introducing a potential for selection bias.
Firstly, all of the included three studies [ 13– 15] enrolled only 270 patients.
