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In adenocarcinomas with defined alterations such as EGFR mutations and ALK translocations, targeted therapies are now first-line standard of care.
27 A first-line standard of care is bevacizumab with combination chemotherapy.
Consequently, a platinum agent plus a new cytotoxic doublets remain the first-line standard of care for patients with advanced, inoperable NSCLC.
Although D/P combination has become the first-line standard of care for advanced CRPC, PSA responses rarely exceed 50% and median survival is less than 20 months.
Platinum-based combination chemotherapy prolongs survival in patients with NSCLC who have a good performance status and remains the first-line standard of care [ 3].
Plerixafor is a more effective and less toxic mobilising agent than conventional chemotherapy (especially in heavily pretreated patients), with comparable subsequent outcome, and merits consideration as the first-line standard of care for stem cell mobilisation.
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Cisplatin, in combination with pemetrexed, is currently the first-line standard-of-care chemotherapy for patients with NSCLC.
The comparator agents were the other current European Society for Clinical Microbiology and Infectious Diseases-recommended first-line standards of care, the echinocandins caspofungin and micafungin [ 12], and (based on data from the trial by Reboli and colleagues) the generic and frequently used azole, fluconazole [ 15].
Bevacizumab is being incorporated as first-line therapy with standard-of-care chemotherapy on epithelial ovarian carcinoma (EOC).
The overall findings of this study are consistent with a study comparing first-line nintedanib with standard-of-care sorafenib in 95 Asian patients with advanced HCC (Cheng et al, 2015).
Although DC has been rekindled in different studies, this procedure is neither first-line treatment nor standard of care in severe TBI.
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