Sentence examples for first-generation agents from inspiring English sources

13 941 received first-generation agents and 27 966 received second-generation agents.

Effective antihistamines in combinations are first-generation agents, such as dexbrompheniramine and chlorpheniramine.

First-generation agents were filled with room air, which had the disadvantage to diffuse quickly into surrounding plasma.

Most studies show the second-generation antipsychotics to have greater diabetes-causing effect than first-generation agents such as chlorpromazine and haloperidol (24).

For the first-generation agents, the most common 'non-SMI' mental health diagnoses that we identified were anxiety, depression, sleep disorders and dementia (especially for haloperidol).

Between 12% and 17% of the people who had been prescribed first-generation agents had no record of an SMI or of any non-SMI mental health diagnosis.

Over the five years of the study (2007 2011), the rates of prescribing for each first-generation agent decreased, while quetiapine prescription rates increased the most over time.

Bevacizumab (Avastin), a humanized VEGF-A neutralizing antibody, represents the first-generation agent of anti-tumor angiogenesis and has been approved to treat several types of malignancies in combination with cytotoxic chemotherapy, including colon, lung, and renal cancers [ 32].

If platinum-based therapy is contraindicated, single or combination use of third-generation agents or TKIs may be considered, although studies generally show lower response rates with these regimens than with platinum-based therapies [ 3].

Pharmacodynamic innovation with regard to the dihydropyridines began with the third-generation agents (amlodipine, nitrendipine).

With the advent of second-generation agents that for the first time specifically target individual HCV proteins, HCV-specific therapy has arrived.