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However, during the first year of circulation, mutations in the surface glycoproteins of the pandemic virus may accumulate at random until a most fit variant has established itself and further evolution takes a more linear rate.
Other studies have reported overall lower mortality rates associated with the first year of circulation of the 2009 pandemic virus, compared with that of seasonal influenza, but have found a higher disease burden for children and young adults (4,21 25).
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In all, an estimated 12,000 deaths occurred in the United States during the first year of pandemic circulation [ 126].
Using 2 epidemiologic techniques for calculating rates, we found that ≈1% of the Davidson County, Tennessee, population had visited an emergency department for influenza A(H1N1 pdm09 during the first year of virus circulation.
In 2012, Time Out London dropped its £3.25 price and bumped circulation to 305,000, growing revenue by 80% within the first year of the change.
The First Year of Grad School.
Condé Nast's UK edition of Wired hit its first year circulation target of 50,000 but only by giving away 10,000 copies.
During the first years of the long, slow slide in daily newspaper circulation, Sunday newspapers were the industry's hope and consolation.
The Brixton pound has just celebrated its first year in circulation.
The magazine made a modest $700 profit in its second year of publication; by 1928 its profits were $125,000 on a circulation of 200,000.
By 1862, the second year of the Civil War, government-issued coinage began vanishing from circulation.
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