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This is the first trial to explore comprehensively the genome-wide gene spatial and temporal expression patterns of drought responsiveness in rice.
In this context, it is also the first trial to explore whether changes in the quality of traumatic memories and posttraumatic cognitions are potential candidates for effective mechanisms of change in PTSD symptom reduction among war-affected children in treatment.
To the best of our knowledge, this is the first trial to explore the association between SNPs with a potential influence on L-OHP, CPT-11 and capecitabine and the clinical outcome with the use of a triplet cytotoxic regimen.
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The first clinical trial to explore the impact of IL-12 CAR-T cells has been opened by MSKCC (NCT02498912), where IL-12-secreting CAR-T cells transduced with a 28ζ CAR targeting mucin-16 (MUC-16) is being tested in patients with ovarian cancer.
This phase II, randomized, multicenter study was the first clinical trial to explore the use of belatacept in LT recipients.
This ongoing trial will be the first prospective randomized trial to explore the efficacy of nab-paclitaxel as the first-line treatment specifically in squamous carcinoma of lung.
The BREATHE-2 was the first randomized, double-blind, placebo-controlled trial to explore the potential clinical benefits of combining oral bosentan with epoprostenol in 33 patients with severe PAH (WHO functional class III/IV) [ 45].
This is the first trial to have explored the use of medium-term (6-months) antibiotic prophylaxis in patients who have had cellulitis of the leg.
We also compared error rates by trial to explore differences in data quality across trials.
A separate group of researchers, also at Boehringer Ingelheim, completed their first clinical trials to explore flibanserin as a libido-enhancer in 2008.
He currently leads and co-leads the first randomized trials to explore the implementation of medical sequencing in adults (MedSeq Project) and newborns (BabySeq Project).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com