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This article gives an overview of the clinical manifestations, diagnosis and symptomatic management of patients with MPS II and provides, for the first time, recommendations for the use of ERT.
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Patients with previous clinical trial experience have fewer concerns than those facing this option for the first time, and recommendations by clinicians play a significant role in their decision [ 10].
It was the first time that recommendations were made according to the 'levels of evidence' and exclusively based on 'grading study designs', i.e. RCTs provide good evidence (level I), cohort studies and case control studies provide fair evidence (level II), and expert opinion arising from clinical experience provides poor evidence (level III).
The European foreign ministers, in Luxembourg for their regular monthly meeting, also discussed for the first time the recommendation put forward by the European Commission last week to begin union membership negotiations with Turkey.
Educators unveiled new guidelines on Tuesday that call for sweeping changes in the way science is taught in the United States — including, for the first time, a recommendation that climate change be taught as early as middle school.
It is not uncommon for General Assembly resolutions to call out North Korea and other human rights offenders, but if this resolution makes it to a vote it will be the first time a recommendation has been made to refer the country's leaders to the ICC.
So the first time you see recommendations, the content is highly curated for your needs. . .
As both 12.5 and 25 mg diclofenac potassium were switched from the "prescription only" status to selfmedication in Germany in the last few years, they are considered for the first time in these recommendations.
30 We present a clinical trial designed to obtain, for the first time, evidence-based recommendations on the efficacy of vitamin D3 supplementation, a safe, non-costly therapeutic strategy, in improving physical performance, decreasing fatigue and increasing HRQoL in patients with advanced cancer in palliative care.
Taking into account existing approaches (Gomes et al. 2002; Guéhéneuc and Mustapha 2007; Weiss and Birukou 2007), this work suggests two methodologies from which one is a variation of an existing methodology and the other is used first time for the recommendation of Design Patterns.
For the first time since 1995, government recommendations on alcohol drinking have been updated.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com