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The Beagle voyage succeeded, for the first time, in establishing a linked chain of reference points around the globe of known longitude which could be used by subsequent voyages to calibrate their own chronometers.
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The new price, used for the first time last month in establishing a standard for energy efficiency in new microwave ovens, is 50 percent to 100 percent higher per ton than the one developed in 2010.
"We have, for the first time in humans, established a dose-response curve that applies to electrical stimulation rather than to drugs," said Josef Parvizi, MD, PhD, associate professor of neurology and neurological sciences.
"We have shown for the first time in an established mouse model of anxiety and depression that bacteria play a crucial role in inducing this abnormal behaviour," said Premysl Bercik of McMaster University in Hamilton, Canada, the lead author of the study.
In so doing, he "opened up the courts to environmentalists for the first time in history," establishing the principle that citizens can sue corporations for degrading the air and water, as Mr. Kennedy and Mr. Cronin wrote in their 1997 book, "The Riverkeepers".
Krtiny is a small village in southern Czechia where forestry experts from Eastern Europe, Central Asia and the Czech Republic met for the first time in 2005, establishing cooperation in the area of forestry with the aim of spreading European forestry management standards to Central Asia.
Nevertheless, the US Food and Drug Administration FDAA) states that it requires animal testing on a rodent and nonrodent species in order to determine toxicity in humans, the dose to administer to humans taking a new drug for the first time, in order to establish a margin of safety, and for monitoring purposes during clinical trials [ 26].
A QSAR study was carried out on 34 aminooxadiazoles for the first time in order to establish a quantitative relationship between the PIM1 inhibitory activity and their chemical structures.
This manuscript, likely for the first time in the field establishes a well-defined experimental system: three isogenic cells lines that differ solely in KRAS status.
It was not until after more than three decades of non-direct intervention that Singapore announced in 2012 that it would for the first time in history establish 15 government kindergartens to provide quality and affordable K1 and K2 programs.
Promising morphological, biochemical and functional genomic variation was identified for the first time in a newly established watercress germplasm collection, consisting of 48 watercress accessions sourced from contrasting global locations.
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