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Herein, we report for the first time evidences of a direct role of PHOX2B in the transcriptional regulation of ALK, thus pointing not only at a combined role of these two genes in NB pathogenesis but also suggesting a possible synergistic and joined effect of PHOX2B and ALK in the development and/or maintenance of the sympathetic nervous system.
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BGP's 17 September report effectively acknowledges that this wasn't the first time evidence of indigenous people in "isolation" has been found during its operations, noting that on 12 September a member of Topografia 10 had said, via radio, that they had come across "paths and human footprints".
These findings show, for the first time, evidence of a possible involvement of common variants in GABA receptors in migraine susceptibility and in gender-specific liability.
"We saw for the first time evidence of genotoxic pathways being activated in the cells of the whales," said researcher Amy Bowman.
The present study offers preliminary evidence linking forest proximity to higher visitation rates and presence of wild pollinators on soybean flowers thus providing for the first time, evidence of the forest role as pollinator donor for the soybean crop.
These results provide for the first time evidence of restricted subjective sensitivity to gradients of reward in cocaine addiction and of the involvement of frontolimbic brain regions (including the orbitofrontal cortex) in this deficit.
Our results provide for the first time evidence of adaptive divorce in an invertebrate monogamous species.
The proposed methodology uncovered, for the first time, evidence of the putative role of impared centrosome cohesion in melanoma progression.
The increased expression of osteocyte-related transcripts, such as SOST, DMP1, MEPE, in the spine relative to the ILC, provides for the first time evidence of mechanical stress-related in vivo increase in osteocyte transcriptional activity.
Our study provides, for the first time, evidence of the de novo RNA-polymerase activity and oligomerization of NS5B from genotypes different to genotypes 1 and 2 and propose candidate regions involved in NS5B-NS5B interactions.
We provide here for the first time evidence of a direct and specific interaction between ROCK1 and LIMK 2 in well-spread mesenchymal cells which is absent in rounded blebbing cells.
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