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One caveat of this work is the limited number of genes investigated in the multiple samples analysis, and the fact that our second study, extended on more genes, has been performed with pooled samples.

A second study extended those findings by demonstrating that passive antibody was effective in helping to clear murine infection only if given before or at the same time as a challenge with C. burnetii (34).

In four of these studies wrists and metacarpophalangeal (MCP) joints were assessed as the minimum [ 14- 17]; study-one also evaluated tendons [ 14], study-two also evaluated proximal interphalangeal (PIP) joints [ 15], and the third study extended the core set to metatarsophalangeal (MTP) joints and larger joints, such as the shoulders, knees and ankle [ 16].

We report the first population-based study, extending over 15 years, of cardiovascular LEs in survivors of childhood and young adults with cancer using person-linked electronic health records of specialist cancer registry and administrative hospital admission data.

First, this study extends the literature on the relationship between ownership concentration and international business commitment from both principal-agent and institutional perspectives, in response to the call to study firm structures, corporate governance, and their consequences (Aguilera & Crespi-Cladera, 2016).

First, this study extends the finding to include adjudicated nonfatal CVD events (MI and stroke).

First, this study extends prior research by showing that the detrimental effects of exposure to stressors on mental health in mid-life and late adulthood are buffered by mindfulness, a resiliency factor.

First, our study extends the general applicability of the literature to a broader population of critically ill patients because we examined a non-select population of patients with medical, surgical and neurological/trauma diagnoses as compared with the previous studies that focused only on patients in medical ICUs.

Second, this study extends prior research by examining the relevance of individual auditor certification.

Fourth, this study extends methodological approaches to the inquiry of implementation and organizational improvement in a number of ways.

Sixth, our study extends over three years, and we were not able to take into account for the natural influence in the practice pattern.

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