For full Tfh differentiation, primed T cells then need a second round of antigen presentation from B cells to stabilize Bcl-6 expression and generate Tfh cells that are capable of migrating into B cell follicles and supporting the germinal center response (Deenick et al., 2010; Baumjohann et al., 2011; Choi et al., 2011).
This occurs at a time in the response where B cells provide a second round of antigen presentation to Tfh-precursors, allowing for stabilization of Bcl-6 expression and full differentiation into Tfh cells (Baumjohann et al., 2011; Choi et al., 2011), suggesting that CD28 CD80/86 interactions are important for Tfh differentiation during early T B interactions.
The first round of studies was disseminated by the usual academic journals, papers, and presentations, as was the second round challenge.
[Editors' note: the author responses to the first round of peer review follow.] Thank you for considering our manuscript "Antigen presentation kinetics control T cell/Dendritic Cell interactions and Tfh generation in vivo".
"Halfway through my speech I told them, 'Oh, by the way, this entire presentation is running on Westmere,'" the provisional name for Intel's first round of processor chips etched at 32 nanometers.
First Round of the Draft Smile.
