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In conclusion, the P2Y10 receptor is the first receptor identified as a dual lysophospholipid receptor.
We previously identified lpA1, the first receptor gene for a signaling phospholipid called lysophosphatidic acid (LPA) and showed its enriched expression in the VZ.
Epidermal growth factor receptor (EGFR) was the first receptor to be proposed as the target for cancer therapy, however, the anti-EGFR therapy showed a low response rate clinically.
This was the first receptor which was found to be able to bind both a steroid and a peptide ligand and also to be involved in both defensive and developmental responses.
First, receptor internalization may influence agonist efficacy in different ways.
As in the case of ANTXR1 [1], the ANTXR2 interaction with wild-type PA is absolutely dependent upon the first receptor MIDAS aspartate (D50).
Similar(35)
First, receptors were depleted from the surface of the cells by a 5 min trypsin/EDTA pre-incubation at 37°C.
These analyses give the first receptor-specific classification of auxins and indicate that AFB5 is the preferred site for a number of auxinic herbicides by allowing interactions with analogues having van der Waals surfaces larger than that of indole-3-acetic acid.
Supporting our analysis, Q9W025_Dro and Q9W027_DRo were reported as first receptors specific for Drosophila myosuppressins (Drome-MS) [ 32] and Q9W4H3_Dro was reported as neuropeptide proctolin binding receptor [ 33].
The two first receptors contain a death domain and transduce death signal by direct activation of procaspase 8, whereas TNF-R2 has no death domain.
The efforts have already yielded one major find: a third receptor for histamine, a chemical released in the body in response to stress, inflammation and allergies.
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