The results, given in Table 1, show that CFM-ID generally performed better, indicated by the higher number of correct first ranked candidates (43 vs. 30), top 5 (170 vs. 145), top 10 (232 vs. 226) and a lower median and mean rank of 11 versus 12 and 127 versus 141.
MAGMa+ outperformed MAGMa, showing the use of the parameter optimization performed to improve several second and third ranked candidates to first place.
No candidate secured a first-round victory; however, the incumbent Mesić enjoyed a substantial lead over other candidates, as he received 48.9% of votes, and the second and third ranked candidates Jadranka Kosor (HDZ) and Boris Mikšić (independent) managed only 20.3% and 17.8% of voter support respectively.
When we used only the mutation data, our supervised analysis of mesenchymal subclass identified IDH1 and TP53 as the first and second ranked candidates.
When we used only the CNV data, our supervised analysis of the proneural molecular subclass compared to all others identified OR51E2 and OR52E4 (chr 11p15) as the second and third ranked candidates; CDK4 was the 17th highest ranking CNV.
For each iteration, we first ranked all candidate variants (both experimentally validated and randomly selected) by their final PS scores [Equation (3)].
Based on these properties, the positional candidates were first ranked by formulating a scoring method that assigned Weight value (Wv) to each candidate.
But that is hardly surprising, as the example offered by Johnson over the past eight years was hardly likely to attract first-rank candidates.
Candidate genes were first ranked by three network topological attributes: node degree, node betweenness and by their closeness to known cancer genes in the network (Box C).
On the second ballot, they rank candidates in order of preference.
Voters can rank candidates, so second-preferences count if nobody wins a majority of first choices.
