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The placebo effects were only measurable after 4 weeks of intake, whereas the Perilla extract effects were measurable already in the first part of intervention and were even strengthened with ongoing supplementation.
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The first part of the intervention will involve testing intervention compliance.
In comparison with the first part of the intervention period, the preventable ADEs decreased during the second half of the intervention period - with a rate difference of 1.9/1,000 monitored patient-days (95% CI = 0.4/1,000 to 3.4/1,000, P < 0.05).
In the first part of an intervention period most time is spend working on step 1-3.
Participants may have been discouraged from continuing with Part 2 once they realized that they could not revisit the first part of the intervention.
Thus, in this study, a group-based walking programme will be implemented in the first part of the intervention, accompanied by encouragement of additional home-based walking.
We therefore explored why the recommended therapeutic regimen was not completed in the first part of the intervention (group session) and in the individual visits.
That is, the first part of the intervention program, i.e., preparation for RTW, relates to behavioral determinants such as attitude and (self-) efficacy.
It was possible to reach the majority of PCC visitors with the first part of this intervention, that is, simple screening questions, highlighting the possibility of individual health promotion at the local PCC.
However, few changes in prescribed drugs were made due to the first part of the intervention, that is, the pharmacist recommendations on modifications in drug therapy, 13 and we deem these unlikely to have had a major impact on patient health.
The first part of the brief intervention was carried out before randomization and could be considered as blinded.
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