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The first module includes 10 genes: 8 forming a full cross-related octogonal structure plus 2 nodes linked to them.
The first module includes COG3521 (putative lipoprotein), COG3522, COG3455 (DotU) and COG3523 (IcmF).
The first module includes more than 50 suppressed genes that encode ribosomal proteins or translation regulators.
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The third module includes COG3518 (gp25-like protein), COG3519 (VasA) and COG3520 [ 8].
The second module includes COG3516 (VipA), COG3517 (VipB) and COG3157 (Hcp).
The second module includes up-regulated genes encoding key enzymes associated with glycolysis.
The sixth module included signal transduction (GO 0007165) and other signal pathways related functions.
A third module included genes involved in free radical homeostasis, regulation of the inflammatory response, mitochondrial metabolism and RNA processing.
Similarly, variants of many genes found in the second module, including ETS1, STAT6, VDR, and TYK2, were found to be associated with SLE [ 49- 53].
Performing iMCMC after removal of the foregoing two modules from M results in the third module with three genes (TP53, PTEN and MTAP ) and the fourth module including three other genes (EGFR, NF1 and MDM2 ) and a metagene (CHAT/SLC18A3 ).
The second module included questions assessing basic demographic and health, including age, marital status, education, ethnicity, number of visits to the clinic, gestational age (months), diabetes and gestational diabetes.
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