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Antioxidant treatment seems to be the first line therapeutics in the prevention or treatment of reflux esophagitis.
This latter observation has significant impact on the continued utility of nucleoside analog drugs as first line therapeutics for HIV-1 infection.
Use of dNDPs in HIV-1 DNA synthesis could have significant implications for the efficacy of nucleoside RT inhibitors such as AZT which are first line therapeutics for treatment of HIV infection.
Currently, β1-adrenoceptor antagonists and angiotensin converting enzyme inhibitors or angiotensin receptor blockers are considered equally effective first line therapeutics of DCM.
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Accordingly, Selective Estrogen Receptor Downregulators (SERDs, for example, Faslodex) have been found to be effective inhibitors of ER+ breast tumor growth but their utility is limited to their use as second or third line therapeutics in postmenopausal women with metastatic disease due to their broader impact on physiological ER signaling pathways in normal tissues [ 14, 15].
Non-steroidal anti-inflammatory drugs are also effective first-line therapeutics for ETTH in adults.
Malaria remains a global health burden partly due to Plasmodium parasite resistance to first-line therapeutics.
DMTs are basic therapeutics that include interferon-β (Avonex®, Betaferon®/Betaseron® and Rebif®) and glatiramer acetate (Copaxone®), which are immunomodulators used as first-line therapeutics with more than 20 years of experience.
Fibrosarcoma cells were chosen as the regimen for their treatment contains anthracyclines as first-line therapeutics.
Understanding the mechanisms leading to acquired resistance, therefore, could pave the way to the development of second-line therapeutics.
Most patients with visceral leishmaniasis respond to treatment with antimonials, or with second-line therapeutics, such as pentamidine or amphotericin [ 4].
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