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At the cellular level, accumulation of DU has been observed in various macrophage cell lines (Gazin et al. 2004; Kalinich et al. 2002), and one of the first issues to address is whether DU induces macrophage death and at what level this toxic effect occurs.
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Perhaps the first issue to address is the biggest one: whether to stay at home or not.
When pursuing sustainability initiatives including eco-innovations, the first issue to address is its assessment (Keeble et al. 2003).
In a negative study the first issue to address is methodology.
Though The Times does not want to second-guess, it has issues to address as it reviews its operations in Afghanistan.
Not much is known about what issues to address in first contacts with asylum seekers.
The second hardware issue to address for SPLASSH to operate cameras above the S100 data rate is the camera control computer's Firewire connection.
The first issue to be addressed is the non-economic value -- one would hope it would be a high value -- that we ascribe to human beings based solely on the fact that they exist.
The first issue to be addressed before allocating an available budget M over a time-horizon N, in order to reduce negative impacts of extreme weather events, is the accurate definition of the potential events during this specified period.
A first issue to be addressed is whether there might be some 1st Amendment problems.
The first issue to be addressed concerns using ITT analysis results for the purpose of helping individuals invited to screening to decide whether or not to participate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com