There is a real financial issue to overcome," Dr Dennick said.
Messerschmidt acknowledges that people's ambivalence about their own health is another issue to overcome.
A third issue to be overcome if a GWAS is to give useful results is the choice of the genetic markers themselves.
But first there were some "threshold" issues to overcome, meaning hurdles that had to be passed before an argument about the merits could even begin.
Speaking to the Jewish Chronicle from New York, Corney said the deal could happen "at any time", but that it "wasn't straightforward" and there were "some legal issues" to overcome first.
"On top of that, Nintendo has a couple of specific and thorny issues to overcome with Wii U. One is keeping third-party game publishers on board.
There are still issues to overcome, of course.
There were also significant production issues to overcome.
There are other issues to overcome too.
Nevertheless, they also bring new challenges and issues to overcome.
