Sentence examples for first insufficiency from inspiring English sources

First, insufficiency of the UPR in the ssa1/2 deletion mutant may lead to activation of the ubiquitin-proteasome protein degradation system.

The first insufficiency is its lack of a clear assessment of the impacts of institutionalized competitive disadvantages on smallholder farmers, including, for example, international financial institution support for export-oriented commodity production and the liberalization of international agricultural trade.

First, renal insufficiency reduces insulin clearance and results in prolonged insulin action and hypoglycemia.

Second, ribosome insufficiency, the production of disfunctional ribosomes, or the lack of ribosomes containing a specific r-protein variant could affect the production of specific proteins more than others.

Second, immune insufficiency, a problem also primarily resulting from abnormalities of the GM-CSF signal transduction pathway [ 20], may be augmented by immunosuppressive therapy initiated to treat the condition empirically.

In four cases (methotrexate, 6-mercaptopurine, hydrocortisone and deferiprone) the orphan conditions matches the Priority List indications (acute lymphoblastic leukaemia for the first two, adrenal insufficiency and sickle cell disease, respectively).

It was demonstrated, however, that high levels of NT-proBNP in elderly patients hospitalized with their first ever cardiac insufficiency episode are indicative of increased cardiovascular risks in the follow-up period [ 12].

Third, profound circulatory insufficiency results in metabolic acidosis, which further jeopardizes cardiac performance.