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This is the first harmonization of its kind, providing a proof-of-concept.
They provide first harmonization guidelines for ELISPOT assay and Tetramer staining.
These findings offer first harmonization guidelines that could instantly be accepted by a broad user base.
First, harmonization increases the quantity of usable data and numbers of biospecimens to achieve levels of statistical power necessary to detect effects underlying complex disease etiology.
These served not only as external validation programs for their participants (36 laboratories in panel I, and 29 laboratories in panel II), but also yielded first harmonization steps and guidelines to standardize and validate this assay as a reliable and widely acceptable tool for monitoring of immune responses in clinical trials.
The first harmonization of national surveillance activities in Europe was performed by the Hospitals in Europe Link for Infection Control through Surveillance (HELICS) project, which was funded by the European Commission in the context of Decision 2119/98/EC of the European Parliament and of the Council on communicable disease surveillance and control in EU Member States [ 16].
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Fourth, harmonization of cancer and non-cancer dose response assessments is now increasingly being accomplished on the basis of MOA understanding, and relevant biology and clinical significance, using guidelines described above (e.g. US EPA, 2012f for chloroform and Dourson et al., 2008 for acrylamide).
He traces what he calls the "annexation" of the Bible by astronomy and geology in the sixteenth to nineteenth centuries: harmonization of the biblical account with scientific findings (e.g. the "days as eons" solution) was done to the detriment or obfuscation of both.
First, a harmonization of methodologies for airway sample collection, processing and analysis is required to provide comparable datasets.
Third, the capability for nuclear fuel breeding and incineration of long-lived fission products, and fourth, the harmonization between active and passive safety features.
The design also foresees a protocol for sustaining the first-established harmonization status.
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