Sentence examples for first generation therapy from inspiring English sources

"The first generation therapy we're working on is simply replacing natural protein that declines as we age.

Metastasis is the main cause of breast cancer related deaths, and these metastases are only poorly controlled with first generation therapies such as taxanes [ 2- 4].

Published economic evaluations suggest that atypical (second-generation) antipsychotics are cost-effective when compared with conventional (first-generation) therapy [21].

The hope is that even better second- and third-generation therapies can be developed that can potentially limit the acquisition of resistance.

Limiting the observations to CHOP and third-generation therapies, the authors found a projected 10-years progression-free survival (PFS) and OS of 35 and 44% with CHOP, and 67 and 71% with third-generation therapies, respectively.

Certain LBD mutations are also sufficient to convert AR antagonists to AR agonists and are likely responsible for the 15 30% of patients that exhibit a withdrawal syndrome after cessation of first-generation therapies (e.g. bicalutamide, flutamide) (Small et al, 2004).

By contrast, data from other series suggest that, in this setting, third-generation therapies (usually MACOP-B and VACOP-B) may be more effective than CHOP (Levitt et al, 1982; Todeschini et al, 1990; Bertini et al, 1991; Falini et al, 1995; Cazals-Hatem et al, 1996; Bieri et al, 1999; van Besien et al, 2001; Zinzani et al, 2001, 2002).

Of the patients, 65% (n = 121) were receiving clozapine monotherapy, 24% (n = 45) received a combination of clozapine and second generation antipsychotic therapy (most often aripiprazole), 9.6% (n = 18) received a combination of clozapine and first generation antipsychotic therapy, and 1.6% (n = 3) received both first and second generation antipsychotic therapy in addition to clozapine.

The first generation of therapy will be expensive, Allen said, but the goal is to eventually get the cost down.

First generation cell therapy appears to have addressed safety concerns as well as showing 'activity' in numerous published meta-analyses.

Mesenchymal stem/stromal cells (MSC) are rapidly becoming a leading candidate for use in tissue regeneration, with first generation of therapies being approved for use in orthopaedic repair applications.