first generation drug

USAGE SUMMARY

The phrase "first generation drug" is correct and usable in written English.
It is typically used in the context of pharmaceuticals to refer to the original version of a drug that was developed before newer versions or alternatives. Example: "The first generation drug was effective, but newer medications have since been developed with fewer side effects."

✓ Grammatically correct

Science

News & Media

Human-verified examples from authoritative sources

Exact Expressions

10 human-written examples

Risk of target lesion revascularisation was similar between first generation drug eluting stents and drug coated balloons.

British Medical Journal

Notably this paradigm has also been observed in pooled analyses of first generation drug eluting versus bare metal stent.

British Medical Journal

As with first generation drug eluting stents, the optimal duration of dual antiplatelet therapy after second generation drug eluting stents has never been conclusively determined.

British Medical Journal

Most of these second generation stents, however, were approved after non-inferiority trials in which they were compared with first generation drug eluting stents.

British Medical Journal

36 No single study has so far suggested a safety issue through over three 37 38 or even five years 39 after cobalt-chromium everolimus eluting stent implantation compared with first generation drug eluting stents.

British Medical Journal

The higher rates of late stent thrombosis and the concern about higher risks of late stent thrombosis after early discontinuation of dual antiplatelet therapy with first generation drug eluting stents, however, have raised safety concerns.

British Medical Journal

Human-verified similar examples from authoritative sources

Similar Expressions

50 human-written examples

The FREEDOM Trial Investigators found that, in patients with diabetes and advanced CAD, CABG was superior to PCI using first generation drug-eluting stents.

Cardiovascular Diabetology

The first generation drugs chlorpromazine, haloperidol, loxapine, methotrimeprazine, perphenazine, pimozide, and the second generation drug ziprasidone accounted for only 7 patients, indicating infrequent use of first generation drugs and the low metabolic risk second generation antipsychotic ziprasidone.

BMC Psychiatry

As is common with first generation drugs, there was significant room for improvement.

ACS Medicinal Chemistry Letters

We also note that the mode of action of these first generation drugs remains unclear and their toxicity profile mediocre.

Epigenetics and Chromatin

Second- and third-generation TKIs have been developed to overcome resistance to first generation drugs, but selecting the appropriate drug has become a challenge.

Blood Cancer Journal

Expert writing Tips

Best practice

When comparing multiple generations of similar drugs, it is best practice to compare side effects and efficacy. It also can be of use to add the name of the drug if you're talking about a specific example.

Common error

Avoid assuming that a "first generation drug" is inherently obsolete or ineffective. While newer drugs may offer advantages, older drugs can still be valuable treatments, especially if newer options are unavailable or unsuitable for a patient.

Linguistic Context

The phrase "first generation drug" primarily functions as a descriptor, specifically an adjective phrase modifying the noun "drug". It categorizes a drug based on its place in the timeline of development relative to newer versions. As Ludwig AI points out, this is accurate and useful in written English.

Expression frequency: Uncommon

Frequent in

Science

70%

News & Media

20%

Formal & Business

10%

Less common in

Academia

0%

Encyclopedias

0%

Wiki

0%

Ludwig's WRAP-UP

The phrase "first generation drug" accurately describes an original version of a pharmaceutical treatment, as confirmed by Ludwig AI. Primarily used in scientific and medical contexts, it serves to differentiate older medications from newer advancements. While newer drugs often offer improvements, it's crucial to avoid assuming that a "first generation drug" is automatically obsolete. Understanding the nuances of this term aids in more informed discussions about pharmaceutical options and their historical context. Related terms include "original drug" and "early drug version". It's best to use this term in scientific and medical contexts to compare different drugs.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

original drug

Focuses on the drug being the initial or original version.

early drug version

Highlights the temporal aspect of the drug's development.

initial drug formulation

Emphasizes the composition and creation of the first drug.

first iteration drug

Uses the term "iteration" to suggest a developmental stage.

pioneer drug

Implies that the drug was among the first of its kind.

legacy drug

Suggests the drug has been around for a while and may be outdated.

predecessor drug

Indicates a drug that came before current options.

older generation drug

Highlights that the drug belongs to an older group of drugs.

previous generation drug

Similar to "older generation", but focuses on drugs that came before.

conventional drug

Suggests a standard or traditional medication, often less innovative.

FAQs

How is a "first generation drug" different from a newer drug?

A "first generation drug" typically refers to the original version of a medication, while newer drugs might be改良 (gǎiliáng) versions designed to improve efficacy, reduce side effects, or overcome resistance.

What are some potential alternatives to using a "first generation drug"?

Depending on the context, you could consider using a "second generation drug" or a "third generation drug" if they offer better outcomes or fewer side effects.

Is a "first generation drug" always less effective than newer drugs?

Not necessarily. While newer drugs are often developed to address limitations of older medications, a "first generation drug" may still be effective and appropriate in certain situations, especially if newer options are not available or suitable.

In what contexts is it most appropriate to use the term "first generation drug"?

The term "first generation drug" is most appropriately used in scientific, medical, or pharmaceutical contexts when comparing the characteristics, efficacy, and side effects of different generations of drugs.