first generation compound

USAGE SUMMARY

The phrase "first generation compound" is correct and usable in written English.
It can be used in contexts related to chemistry, pharmaceuticals, or technology to describe a compound that is the first of its kind or the initial version in a series of compounds. Example: "The researchers discovered a first generation compound that showed promising results in treating the disease."

✓ Grammatically correct

Science

European Polymer Journal

Bioorganic & Medicinal Chemistry Letters

EMBO Molecular Medicine

Life Sciences

BioMed Research International

BMC Cancer

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

Human-verified examples from authoritative sources

Exact Expressions

3 human-written examples

The suitable furan diene was obtained by modifying a methacrylate polymer by its reaction with furfural, a first generation compound derived from renewable resources.

European Polymer Journal

This change led to a second generation compound with increased potency, a 400-fold enhancement in aqueous solubility at pH 4, and improved dog pharmacokinetics relative to the first generation compound.

Bioorganic & Medicinal Chemistry Letters

PTC124 and NB54 resulted in the similar significant increase in read-through (8.0-fold and 7.9-fold, respectively) followed by a 7.2-fold increase by NB30, the first generation compound (Fig 4B, Table 1).

EMBO Molecular Medicine

Human-verified similar examples from authoritative sources

Similar Expressions

57 human-written examples

While HDACi have demonstrated therapeutic utility, many of the first generation compounds are pan-inhibitors.

Life Sciences

However, MB is the first generation compounds and is not selective for HSP70.

BioMed Research International

The second generation Spm analogue N -ethyl-N -(cyclopropyl)-methyl-4,8-diazaundecane (CPENSpm) [ 16] has demonstrated lower toxicity and greater therapeutic efficacy than the first generation compounds.

BMC Cancer

This was achieved by engineering long hydrophobic side chains to the backbone polymer, which maximize hydrophobic interactions with bile acids, adding to the effects of the ionic bonds that bind bile acids in the two first generation compounds.

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

Features are scored for statistical significance and can be utilized to design improved second generation compounds or more target-focused libraries.

Bioorganic & Medicinal Chemistry Letters

Currently, these inhibitors are pre-clinical compounds; however, there is significant increase in the development of second generation compounds that could be tested in a phase I or II trials.

Clinical and Translational Medicine

A series of functionalized aryl boronic acids were synthesized and evaluated as potential inhibitors of factor XIa. Crystal structures of the protein inhibitor complexes led to the design and synthesis of second generation compounds showing single digit micromolar inhibition against FXIa and selectivity against thrombin, trypsin, and FXa.

Bioorganic & Medicinal Chemistry Letters

Many of the first and second generation compounds, like JWH-018 or JWH-007, bare Huffman's initials.

Vice

Expert writing Tips

Best practice

When discussing advancements in pharmaceuticals or materials, use "first generation compound" to clearly denote the original version before improvements or modifications were made.

Common error

Be specific about the properties or limitations of a "first generation compound" rather than simply stating it is old. Provide context on how subsequent generations have improved upon it.

Linguistic Context

The phrase "first generation compound" serves as a descriptor identifying the initial form of a chemical substance, drug, or material. Ludwig shows that it's used to differentiate early versions from later, improved iterations. It functions as a noun phrase.

Expression frequency: Rare

Frequent in

Science

85%

News & Media

8%

Encyclopedias

7%

Less common in

Formal & Business

0%

Reference

0%

Wiki

0%

Ludwig's WRAP-UP

In summary, "first generation compound" is a descriptor typically used in scientific and medical fields to classify the initial version of a substance before further modifications. Ludwig confirms its grammatical correctness and common usage in technical contexts. While it's not incorrect to use it in general contexts, you might want to prefer other descriptors for a more informal setting. Ludwig AI states that it is correct and usable in written English.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

initial generation compound

Replaces "first" with "initial", emphasizing the beginning stage.

early generation compound

Uses "early" instead of "first", highlighting the temporal aspect.

original compound

Focuses on the compound being the original or starting point.

prototype compound

Emphasizes that the compound is a prototype or early model.

first-wave compound

Uses "first-wave" to indicate the compound is part of an initial group.

first iteration compound

Highlights that the compound is the first iteration in a series of developments.

foundational compound

Indicates the compound serves as a foundation for future developments.

primary compound

Replaces "first" with "primary", focusing on its main or principal nature.

lead compound

Highlights that this compound leads the way for others.

pioneer compound

Uses "pioneer" to suggest it's the first of its kind.

FAQs

How is a "first generation compound" different from later generations?

A "first generation compound" is typically the initial version of a compound, often followed by "second generation compounds" or "third generation compounds" with improved properties such as increased potency, reduced toxicity, or better selectivity.

What are common characteristics of a "first generation compound"?

Often, a "first generation compound" serves as a starting point, but may have limitations like lower efficacy, more side effects, or less target specificity compared to later iterations. Improvements are generally observed in "second generation compounds".

Can you provide examples of "first generation compounds" and their successors?

One example is in antihistamines, where first-generation drugs like hydroxyzine are followed by "second generation compounds" like loratadine with fewer sedative effects. Similarly, aromatase inhibitors have evolved through several generations.

In what contexts is the term "first generation compound" typically used?

The term "first generation compound" is commonly used in scientific and medical fields to describe the initial version of a drug, material, or chemical compound before subsequent modifications or improvements are made in "second generation compounds".