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This is the first example of the inhibition of transcription in the system of T7 RNA polymerase by cage metal complexes.
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(F ) Example of the inhibition of GABA (100 μM) induced currents by bicuculline (BICC, 100 μM).
To the best of our knowledge these findings represent the first example of direct pharmacological inhibition of the NS2 autoprotease to block HCV genome replication and exert an antiviral effect.
In summary, we have reported the first example of P. aeruginosa biofilm inhibition with multivalent galactosylated LecA ligands.[ 20] The strongest binding was observed with the second-generation glycopeptide dendrimer GalAG2.
Thus, our data represent the first example of an endogenous metabolic abnormality, namely DM, which is associated with a functional inhibition of the Hh signaling pathway.
This is the first example of which we are aware where proteasome activation occurs in response to autophagy inhibition.
For example, the inhibition of PP1 abolished LTD and activated LTP [15], [16], [37], [38].
The best-studied examples are the inhibition of H3K36 methyltransferases by the PRC1 modification H2AK119u1.
The second example of a natural product that exhibits inhibition of the p53 HDM2 interaction is the enantiomer of hexylitaconic acid isolated from a culture of marine-sponge-derived fungus Arthrinium sp. (Ref. 91).
The FGFR4K ponatinib and FGFR4K FIIN-2, reported here, are the first examples of FGFR inhibitor complexes featuring a DFG-out mode of inhibition.
First, the inhibition of apoptosis on autophagy was determined.
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