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Figure 4 illustrates the timing of the first exacerbation during the study in the 2 arms, and the probability of not having an exacerbation favors the lung flute (p = 0.03).
A previous proteomics study showed increased levels of apolipoprotein D in patients with a clinically isolated syndrome of demyelination, indicating that abundance levels of this protein are highest in MScl patients at the time of their first exacerbation [10], [17].
Analysis of time to a first exacerbation.
23 Exacerbations 24: frequency of exacerbations, time to first exacerbation, severity and duration of exacerbations.
Forest plot assessing hazard ratio (HR) of time to a first exacerbation among patients receiving macrolides compared to placebo.
The National Emphysema Treatment Trial showed that LVRS achieved significant improvements in exacerbation frequency and time to first exacerbation [ 96].
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First, exacerbations could be detected and treated promptly.
All first exacerbations were taken into account, provided that at least three consecutive major symptom free days were counted before exacerbation onset.
During the observational period 75 first exacerbations were observed of which 26 (35%) were severity type 1, 20 (27%) type 2, 19 (25.%) type 3, and 10 (13.%) exacerbations were defined as type 4. At exacerbation onset, most patients reported an increase in dyspnea (81%) and increased cough (51%).
A second exacerbation began in Bukama in August 2002, when fishermen returned from the lakes to sell their catches.
Time to first and second exacerbation and time to first hospitalisation will be registered on the basis of the diary card and interviews.
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CEO of Professional Science Editing for Scientists @ prosciediting.com