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The first dosing with pamidronate caused a transient drop in serum calcium that was asymptomatic and not treated.
This patient died of septic shock, disseminated intravascular coagulopathy and acute respiratory distress syndrome 7 days after first experiencing symptoms (8 days after her first dosing) [64].
Measurements of food consumption were initially carried out during the acclimation period (prior to the first dosing session), followed by weekly measurements throughout the entire observation period.
Subjects had to abstain from caffeine intake 2 days before the first dosing and until the end of the study and cocoa and chocolate were not allowed 24 h before the dosing day.
Plasma drug concentrations were measured in the first dosing interval.
Subjects were observed overnight and discharged 5 days after the first dosing.
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It should be noted that the second dosing-to-first dosing analysis excluded subjects who did not receive or did not complete the second PA dosing due to the occurrence of liver function abnormalities fitting the nonredosing criteria.
She took the first dose.
Dr. Mukherjee injected the first dose himself.
The first doses will be available next year, Dr. Fauci said.
We have 93% coverage with the first dose by the age of two.
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