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The first dose of each course of study drug was administered and supervised at the healthcare unit by a study nurse; subsequent doses of each course were administered and supervised at home by study staff.
Economic costs per child receiving at least the first dose of each course of IPTc show SP bimonthly, at US$8.19, is the cheapest to deliver, followed by AS+AQ bimonthly at US$10.67 and then by AS+AQ monthly at US$14.79.
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Table 2 divides the total costs by the number of children who received at least the first dose of each monthly course of IPTc by drug regimen.
For the analysis of coverage of IPTc, an intention to treat analysis was used in which all children who were enrolled and received the first dose of IPTc course one were included in the analysis.
At between US$8.19 and US$14.79 the annual cost of delivering at least the first one dose of each course of IPTc under trial conditions is higher than that of other interventions designed to protect children against malaria.
Deaths occurring during the intervention period were expressed per 1000 children who received the first dose of at least one course of IPTc and per 1000 PYAR, with the 95% CI and P-value for the corresponding relative risk and rate ratio calculated using standard methods [14].
Acceptable coverage was defined as the proportion of children who received at least the first dose of 3 or more courses of IPTc.
Poor coverage was defined as the proportion of children who received the first dose of two or less courses of IPTc.
The proportion of children who received at least the first dose of 3 or more courses of IPTc was slightly higher in the community based arm (90.5% vs 86.6%; p = 0.059).
Cells were then exposed to 2.5 μg/cm of summer Milan PM10, chosen as the first dose of effects, to investigate the time-course release of IL-1 β.
The speculative course of this first dose of peaceful nuclear energy could get to be as tedious as one of those old school essays on the history of the penny.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com