Bladder volume at first desire to void significantly increased, but maximum cystometric capacity showed no significant change.
These volumes were chosen as fixed values that approximate the commonly observed filling volumes for first desire to void and maximal capacity in patients with DO (see discussion).
In addition, the concentration of ATP in intravesical fluid has been shown to correlate with urinary urgency as indicated by the volume at first desire to void in patients with OAB [ 21, 22].
Moreover, after the intravesical administration of capsaicin, authors observed a reduction of the first desire to void, bladder capacity and pressure threshold for micturition, and an attenuation of symptoms of hypersensitive LUT disorders.
Furthermore, ATP has been shown to play a role in bladder sensation, with ATP concentration in the intravesical fluid correlating with the first desire to void in patients with both overactive bladder [ 3] and painful bladder [ 11] but not in control patients.
In DO, ATP release at 200 mL was significantly higher in those with low first desire to void (FDV) (≤200 mL) than in those with higher FDV (>200 mL); this may suggest that ATP release at early stretch may play an important role in urgency (early sensation) in DO.
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