In contrast to the previously reported studies on SLRR deposition, this work presents the first application of the SLRR protocol in a single-cell configuration using a nonmetal UPD system.
SS has written the first draft of the study protocol.
AF wrote the first drafts of the study protocol.
MIH wrote the grant application, directed the implementation of the study protocol, and had overall responsibility for the research.
Gordon H Guyatt and Holger Schünemann were the principal investigators of the study, wrote the clinical protocol and grant application, are responsible for the study protocol, interpreted data and participated in writing the final as well as early versions of this manuscript.
NK proposed the study idea and led the design and writing of the funding application, as well as development of the study protocol.
Both lung ultrasonography and haemodynamic monitoring are part of routine management protocols in our ICU, and their application was totally independent from the study protocol.
The first application of study product was supervised in the clinic.
The ethics committee of Ulm University has verified and agreed on the study protocol in January 2009 (Application No. 318/08).
Study visits occurred as follows: Day 1 (baseline and 1 h after first application of study drug); Day 2 (24 h ± 4 h after first application of study drug), Day 3 (48 h ± 4 h after first application of study drug) and Day 5 (study end, 96 h + 24 h after first application of study drug).
The first application of chlorine-36 was the study of the migration of ancient groundwater.
