This month, a new antidepressant drug by AstraZeneca – seen as the most likely successor to Seroquel, the firm's second-biggest selling drug – failed its first late-stage trial.
The developer, Ironwood Pharmaceuticals, said the drug, linaclotide, met all the goals in the first late-stage trial testing it as a treatment for the type of irritable bowel syndrome accompanied by constipation.
An experimental drug for depression, developed from studies of how nicotine affects the brain, has failed in its first late-stage clinical trial, the companies developing the drug said Tuesday.
A new type of lipid-lowering drug being developed by Sanofi and Regeneron Pharmaceuticals cut cholesterol levels by about half in its first late-stage clinical trial, the companies will announce on Wednesday.
Arena Pharmaceuticals said Monday that its experimental drug to treat obesity had succeeded in its first late-stage clinical trial, producing results it said would be good enough for regulatory approval.
But those hopes were dashed on Wednesday when the drug failed in its first late-stage clinical trial, dealing a blow not only to patients with Alzheimer's and their families but to the companies developing the treatment — a start-up in San Francisco called Medivation and the world's largest drug company, Pfizer.
[World Business, Section W.] Cancer Drug Fails Late-Stage Trial Genentech said that a drug that aims to block the flow of blood to tumors has failed its first late-stage clinical trial -- a blow to the company and to what has been considered a promising approach to treating cancer.
He observed that David Hung, whom Ramaswamy recruited to lead Axovant, joined the company as CEO from Medivation, a biopharmaceutical company that saw its own hopes to cure Alzheimer's dashed in 2010 when a drug it had concocted failed in its first late-stage clinical trial.
Finally, the first late-stage implementation of a direct alkyne trans-hydrogenation illustrates another recent advance in catalysis that allows chemoselectivity problems, for which the established stoichiometric repertoire has no adequate answer, to be solved.
Second, the late stage (e.g., after perceptual processing) will actively differentiate perceived distractors from targets at low load.
First, they participate in innate defences against invading larvae [ 35, 36]; second, if infection becomes established, they evolve an IL-4-dependent "alternatively activated" phenotype, which is broadly immunosuppressive [ 8, 37]; and third, in late stage infection, they clear the bloodstream of microfilarial forms through a nitric oxide-dependent pathway [ 21, 38].
