Sentence examples for firmly implicated in from inspiring English sources

Deep sleep, REM sleep and even lighter non-REM sleep have all been firmly implicated in learning and creative thinking, to the extent that parts of the brain responsible for memory, facts and events are known to shrink with chronic sleep deprivation.

Inflammation and complement activation are firmly implicated in the pathology of multiple sclerosis; however, the extent and nature of their involvement in specific pathological processes such as axonal damage, myelin loss and disease progression remains uncertain.

We noted the occurrence of several genes firmly implicated in plant defence among the top 300 genes co-expressed with AtMDL3, including PEN2 [ 51], PEN3 [ 52], PAD4/ SAG101 [ 53], SID2 [ 54], EFR [ 55], SOBIR1 [ 56], different WRKY genes [ 57], as well as MLO2 and MLO12 [ 58].

Now that ZNF703 has been firmly implicated in the pathogenesis of luminal B breast cancers, the next challenges will be to determine how expression/function of the encoded protein can be regulated and to determine the major downstream effectors of its oncogenic functions.

In this cohort, several HLA Class II genes have been firmly implicated as determinants of viral outcome (table 2). 5 Other immunogenetic studies of HCV have identified different associations with Class II genes according to the population and genotype under investigation.

Two important pathways determining hyperuricemia have been confirmed (renal and gut excretion of uric acid with glycolysis now firmly implicated).

Our work firmly implicates PDZ-RhoGEF in the physiological control of adipose tissue development, obesity and insulin resistance.

The observation that TSC2−/− cells are very significantly, but not completely, protected from death in starvation firmly implicates the TSC1/TSC2 signaling cascade in the death mechanism.

Although the role of gene duplication in the emergence of novel traits is firmly established, the genomic and/or evolutionary factors implicated in paralogs assuming divergent functional trajectories continue to evoke scrutiny.

To qualify as a potential intermediate phenotype, these measures should meet a number of criteria, including being heritable, implicated in the disorder of interest, being stable over time, and firmly grounded in neuroscience.

He was not implicated in the inquiry.