Due to abundance of native disulfide bonds at receptor chemokine interfaces, disulfide trapping of their complexes can be associated with intramolecular disulfide shuffling and result in misfolding of the component proteins; because of this, evidence from several experiments is typically needed to firmly establish a positive disulfide crosslink.
Unfortunately, the events of life preceded to get in the way and rather than a moment that would plant the recovery community firmly in a positive tone in the world, we got the "War on Drugs" and the "Just Say No" campaigns.
As we wait for news on what will happen to Waterstone's – and whether Tim Waterstone really will be buying back his chain - we should keep our fingers very firmly crossed for a positive outcome.
Though it gave away few secrets, it reinforced the picture of an obscure East German refugee law student transformed into a major political force in West Germany whose handwriting was firmly imprinted as a positive and imaginative force on Europe's troubled postwar history.
"I spend a lot of time in London and firmly believe this is a positive move.
Meulensteen, 49, only arrived at the west London club last month to work under Jol, whom he had known for many years, but firmly believes there must be a positive mental attitude to the challenges ahead.
There is a positive engagement firmly based on our values that we know are not just Canadian values, but in most cases, are universally shared values across the world, that we have work to do and we will do that work".
A positive RIADT firmly supports the influenza diagnosis; a negative result does not confirm its absence.
While Lewis allows that individual reports need not be very credible considered in isolation for coherence to have a positive effect, he is firmly committed to the view that their credibility must not be nil.
Ladak, though, said firmly: "The idea that there would have been a positive side to us being beaten is not one shared by me".
