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For adjuvant trials, the use of disease-free survival (DFS) is an accepted surrogate because, to date, mature follow up of both individual trials and their meta-analyses have consistently confirmed that improvements in DFS subsequently translate into firm improvements in OS.
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It's fair to say that Windows 8 had a rough start to market, and while a firm improvement, Windows 8.1 hasn't been met with the enthusiasm that Microsoft likely hoped.
"Adaptability: Resilient firms are adaptable, commitments to firm improvement and able to dynamically revise aspects of the firm's strategic positioning in response to market shifts rather than sticking to a conventional business routine or adopting a reactive posture.
Finally, a majority of the firms are willing to spend 15 days or less, which is assumed to be far below the minimum for an effective inter-firm improvement programme.
Even though the firm showed improvements in some areas like fixed-income sales and trading, pretax profit at the investment banking unit fell to 993 million francs in the first quarter from 1.5 billion francs in the period a year earlier.
The firm cited improvements to same-store-sales as a catalyst for future stock appreciation and set a price target of $75 per share.
In many production firms it is common practice to financially reward managers for firm performance improvement.
This paper examines the extent to which innovative Spanish firms pursue improvements in energy efficiency (EE) as an objective of innovation.
Worse yet, Marconi's operating profit for the year will plummet a whopping 50%–and that's assuming the firm sees improvement in the second half of the year.
Within the scope of authorized waste managers, firms suggested improvements such as the standardization of fees, a reduction of the time until the issue of waste management certificates, a higher number of inspections, and a change in the current model of a few large construction waste management facilities.
"A lot of the best practices in indexing are not secret," says Dan Culloton, an analyst at Morningstar, an investment-research firm, "and any improvements are incremental.
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