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There is no doubt that a certain level of PEEP is beneficial during VILI [6, 9, 29, 46], but there is no firm demonstration that this level must necessarily be "high" rather than "low" and may be deduced from the presence of a LIP on the PV curve.
By combining developmental genetics tools with tests of fitness in the field, this case study represents an example of a firm demonstration of how changes in developmental genetic pathways can be associated with the emergence of adaptive phenotypes in nature.
There is no doubt that a certain level of PEEP is beneficial during VILI [ 6, 9, 29, 46], but there is no firm demonstration that this level must necessarily be "high" rather than "low" and may be deduced from the presence of a LIP on the PV curve.
The firm demonstration of the occurrence of EndoMT in human fibrotic diseases and further understanding of the molecular mechanisms involved may lead to the pharmacologic modulation or abrogation of this pathway in human fibrotic disorders and may represent a novel therapeutic approach for these devastating diseases.
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CEO of Professional Science Editing for Scientists @ prosciediting.com