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Previous human somatotopy studies using fMRI have been limited not only by scanning resolution [2], [4] but by an underlying premise that fMRI reveals discrete activation "hotspots" in response to cutaneous stimulation [3], [5], like those measured electrophysiologically as the firing output of cells.
Thus, in addition to a role in the firing output of cells, Shal/Kv4 channels, which are localized exclusively to somato-dendritic compartments of cells [23], [24], may function in the dendrites of motoneurons and sensory neurons, modulating the integration of post-synaptic potentials.
Here we investigated how different stimulus intensities modified the firing output of individual neurons in layer 2/3 of the mouse barrel cortex.
Selective whisker removal in the rodent leads to changes in the firing output of layer 2/3 neocortical neurons, a well-characterised form of experience-dependent plasticity (Glazewski & Fox, 1996; Glazewski et al., 1996; Benedetti et al., 2009).
First, we evaluated how a more than 30-fold change in stimulus intensity regulates firing output in control, whisker-intact mice, using a piezo-driven glass rod to deflect individual whiskers.
We assume that HAN firing output is triggered by membrane currents evoked by coreleased OHN transmitters (which generate firing patterns after a further series of interactions with biophysical and geometric properties of the HAN membrane; Haas and Reiner, 1988).
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We next asked what features of OHN input are conveyed by the two HAN firing outputs.
For example Durstewitz [37] has previously demonstrated that a bottleneck or "ghost" of a line attractor could be achieved at a neuronal level through interactions between firing rate output and calcium gated ion channels, generating the climbing firing rate activity of set cells.
For example, PreProcessing task fires output tokens times to the channels c2 and c11 when data arrives from the incoming channel c1.
Exposure times were measured directly from the Fire output of the EM-CCD using an oscilloscope (TDS 210; Tektronix, Inc., Beaverton, OR).
As a result, the output firing rate of the whole neural network is boosted by positive feedback over the output rate of an individual neuron.
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