Interesting, the U-type pre-treated neurons resumed rhythmic firing (Figure 2D1), albeit with a different rhythmic distribution (Figure 2D2).
Nevertheless, careful visual inspection of the individual spike trains revealed clear patterns of regular firing (Figure 2A).
More specifically, they are characterized by short time windows of intense neuron firing followed by longer intervals of sporadic firing (Figure 2c).
In contrast to wild-type motoneurons, which displayed a very stereotypical delay from cell to cell, DNKv4 motoneurons displayed virtually no delay to firing (Figure 6C).
In response to the same tone represented in a neutral chamber, there was very limited or no changes in firing (Figure 6D F, right panels).
This was evident in the amount of current injection required to induce repetitive firing during both prolonged stimuli; wild-type neurons consistently required larger current injections to induce firing (Figure 3C D, 4A).
The simulation suggests that the abrupt transition from single spike (Figure 6Cb) to complex burst firing (Figure 6Cc) is because there exists a threshold above which CaV3.3 channels are self-facilitating.
When the same conditioned tone was delivered to mice in a neutral chamber that was not associated with any event, it did not produce significant changes in firing (Figure 6D, right panel).
Early in the trial, value correlates were found in the reference frame of action value difference (i.e. left minus right saccade value influenced neural firing; Figure 1B, blue), but late in the trial these evolved into correlates of the eventual chosen saccade (left vs. right chosen saccade influenced neural firing; Figure 1B, red) (Kim et al., 2008; Louie and Glimcher, 2010).
Figure 5 figure supplement 1 shows the separate effects of PC2 from ACC and OFC for delay and effort trials respectively, on DLPFC firing; Figure 5 shows the difference in CPD for effort minus delay trials for each region.
