In 1943, McCulloch and Pitts noted that neurons firing action potentials act like binary devices that can either be on or off.
Representative traces (right) of current-clamped DRG cells firing action potentials in response to current injections (blue bars) and 532-nm green light pulses (green pulse).
Spontaneously firing action potentials from 2 distinctly different types of spiking amplitudes were measured.
Cells capable of firing action potentials with any long-term rhythmic components are thus amenable to this technique.
The muscle bends were likely due to motoneurons firing action potentials and releasing acetylcholine onto the post-synaptic muscle fibers.
Individual place cells are typically silent, only firing action potentials when the animal's head is within a certain region of the environment — the cell's place field.
Many neurological pathological conditions result from neurons firing action potentials at higher frequencies than normal, which lead to these cells displaying a tonically depolarized membrane potential.
ABGCs acquire neuronal properties including synaptic inputs and outputs, and capability of firing action potentials 3 to 4 weeks after their birth.
However, when glucose is elevated and KATP-channel activity is reduced, these α cells undergo depolarization and start firing action potential with resultant stimulation of glucagon secretion.
The negative component, PS, provides a measure of cell excitability, the number of granule cells firing action potentials in response to EPSP (Lomo 1971).
The effect of the hypokalaemic periodic paralysis mutations on S4 translocation may be their predominant effect to decrease membrane excitability in channels that have fast inactivated in the process of firing action potentials.
