Note that the AIP pattern is expressed if oscillations underlying spiking are in a relaxation regime (the recovery variable time constant is large comparing to the membrane time constant); otherwise, instead of AIP, the AP pattern is present, as in a network consisting of reciprocally inhibitory integrate-and-fire cell models.
A large body of evidence has revealed that this complex pathway, once activated, regulates origin firing, cell cycle arrest, stabilization, and resumption of stalled forks [ 39– 41].
The median of the estimated compression rate was 9.0, suggesting that similarly to the timing of firing, place cell firing rates were also temporally compressed during replays.
Of course, mice are not people, and a handful of firing cells don't always add up to a conscious experience.
We further evaluated the ability of detecting firing cells in cultures by labeling primary hippocampal cultures with JPW3027.
(B ) Mean frequencies of spontaneous firing (cell-attached) and coefficients of variation from control and Dlx-CKO LCIs.
Passive, unresponsive cells were only found in the SCNA_Tri line, whereas the control and SNCA_Tri_KD lines showed higher numbers of AP-firing cells.
This is relatively easy with the membrane potential and currents for a patched cell, but not for a population of heterogeneously firing cells.
Therefore, we propose that the activation order of recently firing cells during eSWR is controlled by: (a) the spatially selective drive that they receive; and (b) the recent firing history of cells before eSWR.
Our results are the first to suggest this phenomenon may happen in vivo to a subpopulation of phasic firing cells in the PL.
