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As a result of the improved SNR afforded by ultra-high magnetic field, we have been able to show that cortical responses to different fingertips overlap in S1, that the overlap increases from anterior (posterior bank of the central sulcus) to posterior (post-central gyrus) and that most of this overlap is not easily explained by the contributions of veins to hemodynamic blurring.
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Some overlap between responses to the stimulation of adjacent fingertips would be expected due to the spatial blurring introduced by the hemodynamic response, even if the underlying cortical representations did not overlap [Parkes et al., 2005; Shmuel et al., 2007], and this blurring could explain the limited overlap that we found in the posterior bank of the central sulcus.
They overlap.
Interests overlap.
Often, those impressions overlap.
Where did they overlap?
Our results are therefore compatible with the hypothesis that voxels activated in the posterior bank of the central sulcus belong to area 3b, an area in which the cortical representation of adjacent fingertips shows little overlap in primates [Iwamura et al., 1983a; Pons et al., 1987].
This leads to the hypothesis that noninvasive neuroimaging methods recording the aggregate activity of cell populations should reveal spatially overlapping responses to adjacent fingertips in areas 1 and 2, but not in area 3b.
Columns from left to right are original images, hand segmentation results overlapping on original images, fingertip detection by analyzing convex of hand segmentation result, and virtual keyboard interaction.
In conjunction with the improved SNR afforded by ultra-high magnetic field, this small-volume correction allows us to demonstrate overlapping BOLD responses to stimulation of adjacent and nonadjacent fingertips.
Additional quantitative analyses were also performed to estimate: the overlap of fingertips; the proportion of voxels maximally responding to each fingertip stimulation for a range of thresholds; the overlap ratio [Krause et al., 2001; Kurth et al., 2000; Ruben et al., 2006], which is reported at FDR P < 0.05.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com