Sentence examples for finger mutation from inspiring English sources

We note that the ATP hydrolysis rates are very slow and that the effect of the arginine finger mutation is not as drastic as seen with other AAA+ ATPases.

As expected, the Lis1Δ phenotype in S. cerevisiae is not rescued by the arginine finger mutation, because here Lis1 is also required for proper dynein localization (Lee et al., 2003; Markus et al., 2009; Sheeman et al., 2003).

The interactions of SPN-4, MEX-3, and GLD-1 with OMA-1 map to a region containing the two OMA-1 zinc fingers (amino acids 111 188; Y. Nishi and R. Lin, unpublished results), and are abolished by the E141K zinc finger mutation.

The effects of TRAPP and Rabex acidic finger mutations are now tested, and additional mutations in the Rab switch II region are included as requested by the other referees.

In our co-immunoprecipitation experiments, this double serine mutation weakened PER2 binding to a lesser degree than the zinc finger mutations, which did not elicit a similar period-shortening effect.

Myc-tagged full length KREPA3 WT and mutant genes with one or both zinc fingers mutation were amplified from the plasmids pLEW79-A3-TAP, pLEW79-A3ZFm1-TAP, pLEW-A3ZFm2-TAP and pLEW79-A3ZFm1&2-TAP [49], respectively, by using the primers 5'-CCTCGAGCCACCATGAAGCGTGTTACTTCAC-3' and 5'-ATTCATGATCACAGGTCTTCTTCAGAGATCAG-3'.

Our prediction, based on the AML data, would be that the V391I RING finger domain mutation would affect the E3 activity.

Using exome sequencing, Grief et al identified novel GATA2 zinc finger 1 mutation in 2 of 5 biallelic CEBPA (bi CEBPA) AML patients.

By anticipating that recombination the two teams highlighted the risk, gave vaccine researchers a head start in thinking about how to counter it and, by fingering the mutations, spurred surveillance efforts, which have often been half-hearted.Or, rather, they would have done had they been allowed to publish their results.

This zinc-finger-based mutation-independent approach paves the way towards a 'repression replacement' strategy, which is expected to facilitate widespread applications in the development of novel therapeutics for a variety of disorders that are due to gain-of-function mutations.

Moreover, access to unpublished core data from the kConFab sample set has identified that breast tumours from carriers of RING-finger domain mutations with available pathology data (nine tumours) are all high-grade and those with known receptor status (four tumours) are all ER-negative/progesterone receptor-negative.