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Physiologic relevance of TRAF6 autoubiquitination has been inferred from the dual observations that 1) TRautoubiquitinationtisn is detected in vivo upon engagement of TRAF6-dependent receptors, and 2) the TRAF6 RING finger is required for propagating downstream signal transduction.
Given that TRAF6 RING finger is required for NF-κB activation, this observation is consistent with previous reports showing that lack of p50, Rel, RelA or IKKβ barely affected type I IFN production in response to viral infection [41], [42].
The ROQUIN RING finger is required for autoubiquitination and negative regulation of AMPK.
Thus, the iron finger is required for maintaining structural integrity of the TibC dodecamer.
The zinc finger itself does not interact with the Rabs, but the zinc finger is required for the interaction.
The presence of the U box, but not of the RING finger, is required for the E3 activity of the protein [ 14].
Similar(53)
The N-terminal plus the variable regions but not the PHD-finger is required for the dimerization.
Our data demonstrate that palmar scans of wrists and plantar scans of feet are dispensable for the ultrasound composite scores, whereas the investigation of palmar and dorsal sites of fingers is required to achieve sufficient sensitivity to identify PsA-specific pathologies.
No fingers were required.
Patience and spatial visualization skills are helpful in building the robot, and I found that strong, nimble fingers are required to take it apart.
Moreover, often a lot of rake fingers are required to accommodate the wireless channel, rendering it riot favorable from an implementation point of view.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com