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In this contribution a combined CAD-FEM method for the optimization of the geometry of the finger components will be outlined.
Although a library of zinc finger components and protocols to perform screens to identify optimized ZFNs has been made freely available to the academic community (Maeder et al., 2008; Maeder et al., 2009), it can take months for non-specialists to engineer ZFNs that target a genomic site with high efficiency.
The putative PiSLF-containing E3 ligase complex does not appear to contain an SKP1-like protein, but instead contains PiSBP1, which is three times the size of PiRBX1 (the RING-finger component of a conventional SCF complex) and could play the roles of both SKP1 and RBX1 (Hua and Kao 2006).
In particular, the Finger Windows component of the Visual Index and the Visual Learning component of the Learning Index showed significant negative associations with prenatal MeHg exposure [Finger Windows: β = –0.49, 95% confidence interval (CI): –0.98, –0.01; p-value = 0.05; Visual Learning: β = –0.50, 95% CI: –1.01, 0; p-value = 0.05].
A man puts his finger to the component.
Bouhours is attempting to put his finger on some component that is essential to a work of art but which defies description.
At the level of the finger high-frequency components, i.e., the systolic upstroke, are amplified, and low-frequency components, i.e., the diastolic pressure, are attenuated.
Anthony Lewis puts his finger on those components of Italian society that make life in that country so eminently worth living ("A Civilized Society," column, Sept. 8).
We were particularly interested in describing in more detail the interaction between nominal force and finger on various components of movement-related potential (MRP) associated with preparation and execution of isometric force production tasks.
To assess whether the zinc finger is the only component in the Pan2 Pan3 complex that binds directly to RNA, we deleted it from scPan3 and investigated the ability of the truncated scPan2 Pan3 complex to bind RNA.
Interestingly, in mES cells CXXC finger protein 1 (Cfp1), a component of Setd1 histone methyltransferases complex has a preference for CpG clusters and can be recruited to artificial promoter-less CpG clusters that subsequently lead to trimethylation of H3K4, a CpG island promoter signature [ 45, 46].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com