In bacteria, finely tuned gene expression is the main recourse for immediate interaction with the environment, and should be selected to proceed in a rapid, precise and cost-efficient manner.
BER proteins require a finely tuned balance of expression to ensure complete repair of many mutagenic or genome destabilizing base lesions [24], [46], [51] [54].
At the same time, weaker sites can also be specifically advantageous at genes that require finely tuned regulation of expression levels 99.
RUNX1/ETO shares almost three-quarters of its binding sites with RUNX1, suggesting that the equilibrium between these two complexes results in a finely tuned modulation of expression for a wide range of genes.
Indeed, a finely tuned program of gene expression is triggered by partial hepatectomy, so that through specific checkpoints a coordinated regeneration of the tissue is obtained.
A finely tuned regulation of gene expression during embryogenesis and development is crucial for a normal anatomy and physiology.
However, the enhanced linearity would offer finely tuned control over gene expression that may be essential when precise pathway optimization is needed.
miRNAs have been proved to involved in almost every biological process, including cell proliferation, apoptosis, differentiation and stress response, exerting a finely tuned regulation of gene expression (11).
The function and efficiency of a TF is often modulated by its interaction with other proteins to achieve finely tuned regulation of gene expression.
In a study of over 2,800 constructs in yeast, Gertz et al. (52) assembled a library of enhancers with random combinations of operator sites upstream from a promoter, offering a finely tuned range of basal expression.
