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This observation thus highlights the function of AS as an added layer of gene expression regulation, as well as the potential role of AS in fine tuning the functions of proteins in biological pathways relevant to different cell types.
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The interconnected modifications create multiple layer of regulation to fine tune the function of target protein and to determine the functional read-out.
Our data also show that the SIKs regulate macrophage polarization by fine-tuning the functions of transcription factors in these cells, rather than playing an essential role in the activation of the core signalling nodes triggered upon ligation of TLRs.
The UPS plays a central role in fine-tuning the functions of core proangiogenic proteins including VEGF, VEGFR-2, angiogenic signaling proteins such as the PLCy1 and PI3 kinase/AKT pathways, and other non-VEGF angiogenic pathways to regulate the tumor angiogenesis [ 35].
But motif pattern fine-tune the functions of OBPs and CSPs, leading to the minor difference in binding sex pheromone or plant volatiles in different insect Orders.
Motif pattern fine-tune the functions of OBPs and CSPs, leading to the minor difference in binding sex pheromone or plant volatiles in different insect Orders.
Phosphorylation may fine-tune the function of Spc97 and Spc98 or only the combination of phosphorylation events may be essential for the function of the Tub4 complex.
By exchanging the fourth WD repeat the vertebrates could fine-tune the function of the coronin-1D beta-barrel domain.
Among them are the type-A RRs, which are involved in a negative feedback mechanism that helps to fine-tune the function of cytokinin signaling pathway.
Intriguingly, the levels of such neurosteroids are rapidly elevated following acute stress (Purdy et al., 1991; Barbaccia et al., 2001; Morrow et al., 2009) and therefore, they may act to "fine-tune" the function of GABAARs and consequently influence HPA axis activity.
Tuning parameter p can be used to fine tune the function accordingly to fit to different models.
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