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Idiom
Fine tuning.
Small adjustments to improve something or to get it working are called fine tuning.
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The rationale is that these nonconserved positions could be mutated to predictably fine-tune function.
This observation thus highlights the function of AS as an added layer of gene expression regulation, as well as the potential role of AS in fine tuning the functions of proteins in biological pathways relevant to different cell types.
The interconnected modifications create multiple layer of regulation to fine tune the function of target protein and to determine the functional read-out.
Authors of [ 54] suggested that "..sigmoid function can be considered an excellent decision support tool within any scope" and we have been able to fine tune this function by adjusting the λ value as per our data set.
Tuning parameter p can be used to fine tune the function accordingly to fit to different models.
The most abundant microRNA in all samples tested was miR-223, which negatively regulates granulocyte differentiation and fine tunes neutrophil function [38].
Doxorubicin, on the other hand, not only activates the DNA damage pathways but also promotes a series of phosphorylation and acetylation events in p53 that can fine tune p53 function.
As a corollary to this suggestion, modulation of GABAAR function by endogenous neurosteroids may be important in "fine tuning" HPA axis function.
In addition, the idea that Sry may be functionally active in the kidney is one more example of how the SNS can differentially provide fine tuning of organ function.
But beyond this, our observations highlight an interesting paradox of PGF2α/PGE2 in fine tuning adrenal endocrine functions.
Possible reasons may vary from differences in the environment to lineage specific "fine tuning" of proteins functioning as parts of multi-protein complexes.
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