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Fine tuning.
Small adjustments to improve something or to get it working are called fine tuning.
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The rationale is that these nonconserved positions could be mutated to predictably fine-tune function.
The interconnected modifications create multiple layer of regulation to fine tune the function of target protein and to determine the functional read-out.
Authors of [ 54] suggested that "..sigmoid function can be considered an excellent decision support tool within any scope" and we have been able to fine tune this function by adjusting the λ value as per our data set.
Tuning parameter p can be used to fine tune the function accordingly to fit to different models.
Doxorubicin, on the other hand, not only activates the DNA damage pathways but also promotes a series of phosphorylation and acetylation events in p53 that can fine tune p53 function.
The most abundant microRNA in all samples tested was miR-223, which negatively regulates granulocyte differentiation and fine tunes neutrophil function [38].
Thus, network operators have the chance to fine tune the objective function according to their priorities.
This observation thus highlights the function of AS as an added layer of gene expression regulation, as well as the potential role of AS in fine tuning the functions of proteins in biological pathways relevant to different cell types.
Although the current function of these nucleolar isoforms are unknown, their tissue specificity highlights further the possibility that nesprin isoforms may act to fine tune tissue-specific cellular functions, including nucleolar functions.
The prevailing view is that rRNA base modifications serve to fine tune ribosome structure and function.
As a corollary to this suggestion, modulation of GABAAR function by endogenous neurosteroids may be important in "fine tuning" HPA axis function.
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