High-throughput screening techniques appear the most refined tool to identify pivotal players in complex biological processes: combination of different approaches to integrate several platforms can help better explore their fine tuning activity.
The mGluRs provide a mechanism by which glutamate can modulate or fine-tune activity at the same synapses on which it elicits fast synaptic responses.
It receives input from sensory systems of the spinal cord and from other parts of the brain, and integrates these inputs to fine tune motor activity.
Multiple modes of repression could allow Gro to fine tune gene activity in response to promoter context and cellular environment.
These various mechanisms fine tune the activity of the Ras/MAPK cascade through the creation of a negative-feedback loop.
We therefore propose a feed-back loop between miR-206 and LXRα that might be part of an LXR auto-regulatory mechanism to fine tune LXR activity.
We propose that differential binding to NHERF1 and/or NHERF2 and to their different PDZ domains provides a mechanism to fine tune the activity of the hub.
The cerebellum does not initiate movement, it receives input from sensory systems and from other parts of the brain, and integrates these inputs to fine tune motor activity [ 48].
In addition, there is evidence demonstrating that one miRNA can regulate expression of multiple genes of related function in order to fine tune cell activities [23].
It may be speculated that patients who show persistent behaviour might benefit from learning how they can reduce for example their self discrepancies and associated negative emotions and fine tune their activities during the day.
Our data suggest that functional differences among cytosolic Hsp70s provide yet another way to control and fine tune their cellular activity that may be required to cope with various substrates, functions and adverse conditions.
