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In the recent years, new technologies have revealed several key aspects of nuclear spatial organization that showed a fine interplay between the function of nuclear proteins, their 3D organization, and their dynamics.
Ectopic misexpression studies indicate that these attractive and repulsive systems mostly work independently of each other [10], but there is evidence of a fine interplay between systems at the transcriptional level [11], [12] and downstream of receptors.
The fine interplay between the Bcl-2 family anti-apoptotic members and death-promoting members like BAX and p53 ensures a regular apoptotic process, while its disruption causes the loss of programmed cell death (Reed, 1999).
Intrinsic sex-specific specific factors and the proper sexual identity of the fat body are important for courtship behavior orchestrated by DSX and FRU in the brain, suggesting a fine interplay between signaling from the fat body and the sex-specific regulation of the nervous system (Lazareva et al. 2007; Camara et al. 2008).
Single-molecule experiments in which a nucleosome was placed downstream of the transcribing Pol II have shown that advancement of the enzyme through the barrier depends on a fine interplay between the enzyme dynamics (including pausing and translocation), and the fast dynamics of nucleosomal fluctuations.
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A fine interplay exists between the acquisition of water by roots in drying soil and water loss through transpiration.
However, it should also be noted that we did not detect significant difference between patients who had isolated PTSD from those who had PTSD and LBP in all four dimensions of quality of life estimation, thus suggesting the fine interplay and sometimes unclear boundary between these two groups of patients.
This concept is exemplified by the gut mucosa, featuring fine-tuned interplay between the resident flora in the lumen and the immune cells in the lamina propria, with the epithelium as an interface.
Our study demonstrates that the fine-tuned interplay between ATP and different surface molecules recognizing or modifying ATP can control inflammatory and cell death decisions.
Given that OPRs are implicated in JA biosynthesis, we expect a fine-tuned interplay between SA and JA/ET signaling pathways [ 95].
Finally with this data, we provide a platform to determine in fine detail, the interplay between chromatin architectural proteins, epigenetic factors (histone PTMs, PTMs on CAPs themselves, DNA methylation) and gene expression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com