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Thirdly, although this approach could reveal genes that are potentially broadly methylated in breast cancer, fine demarcation and exquisite phenotyping of breast cancer cell lines is required for a cell-culture-based approach to deliver revealing DNA methylation signatures that differentiate breast cancer subtypes or signatures that have prognostic value.
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Relics from the era — bone (or more commonly plastic) head-models, incised with fine lines showing the demarcation of the zones — continue to sell well, most usually as hat stands.
An 1892 quotation about aitch-dropping shows how rigorous such demarcations could/can be: "A very fine young man, but evidently a nobody, inasmuch as he dropped his aitches and so on".
He broke down job demarcation by encouraging subeditors to write – with fine results – and showcased the work of Denis Thorpe and Don McPhee, two of the most lauded press photographers in the UK, as well as the likes of the art critic Waldemar Januszczak.
No class demarcation intended.
Are the demarcations a legitimate tool in improving the quality of wine and in making it easier for the consumer to purchase fine wine?
Early scientists defied that demarcation.
The line of demarcation is not clear.
There are no rigid demarcation lines.
Make colour work harder than for demarcation.
There is no line of demarcation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com