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In light of the current findings, trials including un-taped controls in their exercise components, as well as further research examining muscle activity in the foot during taped exercise, are warranted.
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In the light of these findings, trial implementers can oversee possible factors that can influence retention of those who will volunteer in the future trials.
In addition to this overview, we propose some further directions for designing pediatric dose-finding trials.
We also reviewed the design used in published dose-finding trials in pediatric oncology over the period 2009 2014.
In phase I dose-finding trials, ICL 670A was well tolerated and had a good safety profile.
The objectives, place and role of paediatric dose-finding trials are investigated in the era of molecularly targeted agents (MTAs).
Dose finding trials using model-based methods have the ability to handle the increasingly complex landscape being seen in clinical trials.
Although many drugs require dose individualisation in clinical practice, dose-finding trials usually aim to identify an optimal dose for the patient population.
Therefore, response-based dose titration should be considered for dose-finding trials, where appropriate, for drugs that will eventually be used this way in the clinic.
[1998 Practical implementation of a modified continual reassessment method for dose-finding trials. Cancer Chemother. Pharmacol. 41, 429 436] and Whitehead and Williamson [1998.
In this paper, we propose an adaptive randomization design for Phase 2 dose-finding trials to optimize Net Present Value (NPV) for an experimental drug.
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